Issue 14, 2009
From the journal:

Dalton Transactions

Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent

Byung-Il Lee,a   Kyung Sig Lee,a   Jung Hee Lee,b   In Su Lee*a  and  Song-Ho Byeon*a  

* Corresponding authors

a Department of Chemistry & Advanced Material Sciences, College of Environment and Applied Chemistry, Kyung Hee University, Gyeonggi-do, Korea
E-mail: insulee97@khu.ac.kr, shbyun@khu.ac.kr
Fax: 82-31-202-7337
Tel: 82-31-201-2457

b Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Abstract

A layered gadolinium hydroxychloride (LGdH), [Gd2(OH)5(H2O)x]Cl, was synthesized from an aqueous solution of GdCl3·6H2O. The X-ray diffraction (XRD) and the selected area electron diffraction (SAED) studies showed that this compound crystallizes in the orthorhombic structure (a = 12.88(4) Å, b = 7.30(2) Å, and c = 8.46(3) Å) which is isostructural with [Eu2(OH)5(H2O)x]Cl. Interestingly, this layered material was readily dispersed and led to a stable colloidal nanosheet in aqueous medium. The obtained colloidal solutions were characterized by the evaluation of their stability in acidic solution, their in vitro cytotoxicity, and their magnetic resonance imaging (MRI) relaxation properties. It is reported that the relaxometry analysis of LGdH suspensions exhibits a sufficient contrast effect for T1 weighted magnetic resonance imaging.

Graphical abstract: Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent

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Article information

DOI
https://doi.org/10.1039/B823172A
Article type
Paper
Submitted
24 Dec 2008
Accepted
19 Jan 2009
First published
13 Feb 2009

Dalton Trans., 2009, 2490-2495

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Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent

B. Lee, K. S. Lee, J. H. Lee, I. S. Lee and S. Byeon, Dalton Trans., 2009, 2490 DOI: 10.1039/B823172A

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